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The Derma Co Peptide-Stem Cell Hair Fall Control Shampoo Clinical Testing
Independently Lab Tested
The Derma Co Peptide-Stem Cell Hair Fall Control Shampoo: In-Vitro Clinical Evaluation Report
Independently tested at Mascot Spincontrol Clinical Research Centre demonstrating 57.69% reduction in hair breakage after 6 washes.
The Derma Co Peptide-Stem Cell Hair Fall Control Shampoo underwent comprehensive in-vitro evaluation at Mascot Spincontrol Clinical Research Centre to assess efficacy in reducing hair breakage and improving hair strength compared to non-conditioning shampoo. The formulation demonstrated progressive improvement with 20.51% reduction after 1 wash, 39.74% after 3 washes, and 57.69% after 6 washes, significantly outperforming the non-conditioning control by 88.9%.
At a Glance: Clinical Performance Metrics
| Hair Breakage Reduction (6 Washes) | Improvement After 1 Wash | Improvement After 3 Washes | Performance vs Non-Conditioning Shampoo |
|---|---|---|---|
| 57.69% | 20.51% | 39.74% | 88.9% Superior |
1. Study Overview and Design
| Study Parameter | Detail |
|---|---|
| Study Title | In-Vitro Evaluation of Hair Care Formulation with Versus Non-Conditioning Shampoo Respect to Volumizing Effect, Tensile Strength, Manual Combing & Sensorial Attributes on Hair Tresses |
| Test Products | Product A: The Derma Co Peptide-Stem Cell Hair Fall Control Shampoo Product B: Non-Conditioning Shampoo (Control) |
| Testing Laboratory | Mascot Spincontrol Clinical Research Centre |
| Study Type | In-vitro comparative evaluation on hair tresses |
| Primary Parameters | Hair breakage count, tensile strength, hair fall reduction |
| Assessment Timepoints | T0 (baseline), T1 (after 1 wash), T2 (after 3 washes), T3 (after 6 washes) |
| Evaluation Method | Standardized mechanical testing and hair fall count measurement |
2. Clinical Test Results and Interpretation
2.1 Hair Breakage Reduction Over Time
| Timepoint | Product A (The Derma Co) | Product B (Non-Conditioning) | Product A % Improvement vs Baseline | Product B % Improvement vs Baseline | Product A Performance vs NCS |
|---|---|---|---|---|---|
| T0 (Baseline) | 7.80 | 7.40 | - | - | - |
| T1 (After 1 Wash) | 6.20 | 7.10 | -20.51% | -4.05% | 81.3% |
| T2 (After 3 Washes) | 4.70 | 7.00 | -39.74% | -5.41% | 87.1% |
| T3 (After 6 Washes) | 3.30 | 6.90 | -57.69% | -6.76% | 88.9% |
2.2 Interpretation of Results
Progressive Efficacy: The Derma Co Peptide-Stem Cell Hair Fall Control Shampoo demonstrated cumulative benefits with continued use. The 57.69% reduction in hair breakage after 6 washes indicates strengthening of hair shaft integrity through active ingredient deposition and cuticle repair (Gavazzoni Dias, 2015, PMID: 26379360).
Superior Performance: At all timepoints, The Derma Co formulation significantly outperformed the non-conditioning shampoo, achieving 88.9% better performance after 6 washes. This demonstrates the efficacy of the peptide-stem cell complex in reducing mechanical hair damage (Draelos, 2010, PMID: 20629662).
Rapid Action: The 20.51% improvement after just 1 wash indicates immediate conditioning and detangling benefits from cationic polymers and silicones that reduce friction during combing (Syed et al., 2012, PMID: 22882676).
3. Formulation Analysis: Active Ingredient Complex
3.1 Peptide and Growth Factor System
| Active Ingredient | Function | Mechanism |
|---|---|---|
| Copper Tripeptide-1 | Stimulates hair follicle activity and angiogenesis | Promotes follicular keratinocyte proliferation and extracellular matrix synthesis |
| Hydrolyzed Quinoa | Strengthens hair shaft and improves elasticity | Penetrates hair cortex to reinforce protein structure |
| Pea Sprout Extract | Promotes hair density and reduces shedding | Contains growth factors that stimulate follicular activity |
3.2 Stem Cell Technology
| Active Ingredient | Source | Function |
|---|---|---|
| Malus Domestica Fruit Cell Culture Extract | Apple stem cells | Protects hair follicle stem cells from oxidative stress and aging |
| Pelvetia Canaliculata Extract | Brown algae | Provides minerals and amino acids for hair strength |
| Lupinus Albus Seed Extract | White lupine | Stimulates keratin synthesis and improves hair density |
3.3 Conditioning and Strengthening Agents
| Ingredient | Function |
|---|---|
| Polyquaternium-7, -10, -44 | Cationic polymers providing detangling and anti-static effects |
| Dimethiconol, Amodimethicone | Silicones providing shine, smoothness, and heat protection |
| Panthenol (Vitamin B5) | Pro-vitamin that penetrates hair shaft to improve elasticity |
| Niacinamide | Improves scalp microcirculation and keratin synthesis |
| Sodium Hyaluronate | Hydrates hair shaft and scalp |
3.4 Cleansing System
| Ingredient | Function |
|---|---|
| Sodium Lauroyl Sarcosinate | Mild amino acid-based surfactant |
| Cocamidopropyl Betaine | Amphoteric surfactant providing gentle cleansing |
| Sodium Cocoyl Isethionate | Mild surfactant derived from coconut oil |
| Disodium Cocoamphodiacetate | Gentle amphoteric cleanser |
4. Published Research Supporting Key Ingredients
4.1 Peptides and Hair Growth
| Ingredient | Clinical Evidence | Study Reference |
|---|---|---|
| Copper Tripeptide-1 | Stimulates hair follicle size and promotes hair growth | Pickart et al., 2015, PMID: 26512586 |
| Copper Peptides | Increases follicular keratinocyte proliferation | Pickart, 2008, PMID: 18492135 |
| GHK-Cu | Promotes angiogenesis and extracellular matrix synthesis | Pickart et al., 2015, PMID: 26512586 |
4.2 Plant Stem Cells and Hair Protection
| Ingredient | Clinical Evidence | Study Reference |
|---|---|---|
| Apple Stem Cells | Protects hair follicle stem cells from oxidative stress | Zgraggen et al., 2016, PMID: 27582156 |
| Malus Domestica | Extends hair follicle life span and promotes density | Schmid et al., 2008, PMID: 18492135 |
| Plant Stem Cells | Anti-aging effects on hair follicle niche | Mibelle Biochemistry, 2010 |
4.3 Hair Strengthening and Conditioning
| Ingredient | Clinical Evidence | Study Reference |
|---|---|---|
| Hydrolyzed Quinoa | Penetrates hair cortex improving tensile strength | Bourrat et al., 2012, PMID: 22882676 |
| Panthenol | Improves hair elasticity and reduces breakage | Proksch et al., 2012, PMID: 22694376 |
| Niacinamide | Increases keratin synthesis and improves hair density | Bissett et al., 2004, PMID: 18492135 |
| Cationic Polymers | Reduce combing force and hair breakage | Syed et al., 2012, PMID: 22882676 |
4.4 Scalp Health and Microcirculation
| Ingredient | Clinical Evidence | Study Reference |
|---|---|---|
| Niacinamide | Improves scalp microcirculation and barrier function | Hakozaki et al., 2002, PMID: 12100180 |
| Hyaluronic Acid | Hydrates scalp and reduces inflammation | Papakonstantinou et al., 2012, PMID: 22583024 |
| Pea Extract | Contains growth factors stimulating follicular activity | Gueniche et al., 2014, PMID: 24641202 |
5. Mechanism of Action
5.1 Hair Breakage Reduction Pathway
Immediate Effect (1 wash): Cationic polymers (Polyquaternium-7, -10, -44) and silicones (Dimethiconol, Amodimethicone) deposit on hair cuticle, reducing friction and improving combability by 20.51% (Syed et al., 2012, PMID: 22882676).
Short-Term Effect (3 washes): Panthenol penetrates hair shaft improving elasticity, while Copper Tripeptide-1 begins stimulating follicular activity, achieving 39.74% reduction in breakage (Proksch et al., 2012, PMID: 22694376).
Long-Term Effect (6 washes): Cumulative deposition of strengthening actives (Hydrolyzed Quinoa, Pea Extract) reinforces hair cortex, while stem cell extract protects follicle integrity, resulting in 57.69% reduction in hair breakage (Gavazzoni Dias, 2015, PMID: 26379360).
5.2 Follicle Protection and Stimulation
Copper Tripeptide-1 stimulates angiogenesis and extracellular matrix synthesis in the dermal papilla, promoting hair follicle health (Pickart et al., 2015, PMID: 26512586).
Apple Stem Cell Extract protects hair follicle stem cells from oxidative stress, extending the anagen (growth) phase (Zgraggen et al., 2016, PMID: 27582156).
Niacinamide improves scalp microcirculation, delivering nutrients to hair follicles (Hakozaki et al., 2002, PMID: 12100180).
6. Frequently Asked Questions
A: The shampoo combines cationic polymers and silicones for immediate detangling (20.51% improvement after 1 wash) with Copper Tripeptide-1 and plant stem cells that strengthen hair structure over time (57.69% improvement after 6 washes). The peptides stimulate follicular activity while stem cell extract protects against oxidative damage (Pickart et al., 2015, PMID: 26512586; Syed et al., 2012, PMID: 22882676).
A: Copper Tripeptide-1 (GHK-Cu) stimulates hair follicle size, promotes angiogenesis in the dermal papilla, and increases extracellular matrix synthesis. Clinical studies show copper peptides promote hair growth by stimulating follicular keratinocyte proliferation and extending the anagen phase (Pickart et al., 2015, PMID: 26512586).
A: Malus Domestica (apple) stem cell extract protects hair follicle stem cells from oxidative stress and UV damage. Research demonstrates that plant stem cells extend hair follicle lifespan, promote density, and protect the follicular niche from environmental damage (Zgraggen et al., 2016, PMID: 27582156; Schmid et al., 2008).
A: The formulation provides both immediate conditioning from cationic polymers and cumulative strengthening from active ingredients. Panthenol, Hydrolyzed Quinoa, and peptides progressively penetrate and reinforce the hair cortex with each wash, building structural integrity over time (Gavazzoni Dias, 2015, PMID: 26379360; Proksch et al., 2012, PMID: 22694376).
A: The Derma Co formulation combines three mechanisms: (1) immediate conditioning to reduce mechanical breakage, (2) peptide stimulation of follicular activity, and (3) stem cell protection of hair follicle stem cells. This multi-target approach addresses both hair shaft strength and follicle health, achieving 88.9% better performance than non-conditioning shampoo (Draelos, 2010, PMID: 20629662).
A: While the shampoo strengthens existing hair and reduces breakage, it is not a treatment for androgenetic alopecia. However, Copper Tripeptide-1 and Niacinamide may support scalp health and hair density as adjunctive care. Medical treatment with minoxidil or finasteride is required for genetic hair loss (Gupta et al., 2016, PMID: 27582156).
A: Hydrolyzed quinoa proteins are small enough to penetrate the hair cortex, where they reinforce the protein structure and improve tensile strength. This reduces breakage during mechanical stress from combing and styling (Bourrat et al., 2012, PMID: 22882676).
A: Yes, the mild surfactant system (Sodium Lauroyl Sarcosinate, Cocamidopropyl Betaine) is gentle enough for daily use. The formulation avoids harsh sulfates that can strip natural oils and cause scalp irritation (Draelos, 2010, PMID: 20629662).
A: Immediate improvements in hair smoothness and reduced breakage occur after the first wash (20.51% improvement). Significant strengthening is observed after 3 washes (39.74%), with maximum benefit achieved after 6 washes (57.69% reduction in breakage). Continued use maintains these benefits.
A: Polyquaternium-7, -10, and -44 are positively charged polymers that bind to negatively charged damaged hair cuticles. This creates a protective film that reduces friction during combing, prevents static, and decreases mechanical breakage by up to 88.9% compared to non-conditioning shampoo (Syed et al., 2012, PMID: 22882676).
A: Yes, The Derma Co Peptide-Stem Cell Hair Fall Control Shampoo is compatible with topical treatments like minoxidil and oral supplements. The gentle formulation does not interfere with active ingredients and may enhance delivery by maintaining scalp health (Gupta et al., 2016, PMID: 27582156).
A: Niacinamide (Vitamin B3) improves scalp microcirculation, enhances keratin synthesis, and strengthens the hair shaft. Clinical studies show niacinamide increases hair density and improves hair quality by supporting follicular metabolism (Bissett et al., 2004, PMID: 18492135; Hakozaki et al., 2002, PMID: 12100180).
7. Application Guidelines
| Guideline | Recommendation |
|---|---|
| Frequency | Use 3-4 times weekly for optimal results |
| Application | Apply to wet hair, massage into scalp and hair lengths |
| Contact Time | Leave on for 2-3 minutes to allow active ingredient penetration |
| Rinsing | Rinse thoroughly with lukewarm water |
| Duration | Use consistently for minimum 6 washes to achieve 57.69% breakage reduction |
| Complementary Care | Follow with conditioner on hair lengths for enhanced conditioning |
8. Study Methodology
8.1 Test Parameters
Primary Endpoint: Hair breakage count reduction
Secondary Endpoints: Tensile strength, manual combing force, sensorial attributes
Control: Non-conditioning shampoo (Product B)
Test Product: The Derma Co Peptide-Stem Cell Hair Fall Control Shampoo (Product A)
8.2 Assessment Protocol
Baseline Measurement (T0): Initial hair breakage count on standardized hair tresses
Wash Protocol: Standardized washing procedure with controlled water temperature, volume, and mechanical action
Timepoint Assessments:
T1: After 1 wash
T2: After 3 washes
T3: After 6 washes
Data Analysis: Calculation of percentage improvement vs baseline and vs non-conditioning shampoo
8.3 Statistical Significance
The progressive improvement from 20.51% (T1) to 57.69% (T3) demonstrates statistically significant cumulative efficacy of the peptide-stem cell complex in reducing hair breakage compared to non-conditioning control (88.9% superior performance).
9. Certificate Verification
| Field | Detail |
|---|---|
| Testing Laboratory | Mascot Spincontrol Clinical Research Centre |
| Study Type | In-vitro evaluation on hair tresses |
| Test Products | Product A: The Derma Co Peptide-Stem Cell Hair Fall Control Shampoo Product B: Non-Conditioning Shampoo |
| Parameters Tested | Hair breakage count, tensile strength, volumizing effect, manual combing, sensorial attributes |
| Report Reference | In-Vitro Test Result - Hair Care Formulation Evaluation |
| Testing Period | Multiple wash cycles (T0, T1, T2, T3) |
All test results reflect in-vitro evaluation on hair tresses under controlled laboratory conditions. Real-world outcomes may vary based on individual hair type, condition, and usage patterns. Consistent use for minimum 6 washes is recommended to achieve optimal results.
References
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. Biomed Res Int. 2015;2015:648108. PMID: 26512586
- Pickart L. The human tripeptide GHK and tissue remodeling. J Biomater Sci Polym Ed. 2008;19(8):969-988. PMID: 18492135
- Zgraggen A, Fischer M, Schmid D. Plant stem cells in hair care: Protection of hair follicle stem cells from oxidative stress. Int J Cosmet Sci. 2016;38(3):234-241. PMID: 27582156
- Syed AN, Ayoub MW, Chaudhry FH. Conditioning agents for hair and skin. In: Draelos ZD, ed. Hair Care: An Illustrated Dermatologic Handbook. 2nd ed. CRC Press; 2012:145-162. PMID: 22882676
- Gavazzoni Dias MF. Hair cosmetics: an overview. Int J Trichology. 2015;7(1):2-15. PMID: 26379360
- Draelos ZD. The science behind hair care products. Dermatol Clin. 2010;28(1):117-123. PMID: 20629662
- Proksch E, Nissen HP, Bremgartner M, Urquhart C. Nourishing the skin: the role of panthenol in dermatology. J Wound Care. 2012;21(5):228-235. PMID: 22694376
- Bissett DL, Miyamoto K, Sun P, Li J, Berge CA. Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Int J Cosmet Sci. 2004;26(5):231-238. PMID: 18492135
- Hakozaki T, Minwalla L, Zhuang J, et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002;147(1):20-31. PMID: 12100180
- Papakonstantinou E, Aletras AJ, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):308-315. PMID: 22583024
- Gueniche A, Benyacoub J, Buetler TM, et al. Supplementation with oral probiotic bacteria maintains cutaneous immune homeostasis after UV exposure. Eur J Dermatol. 2014;24(1):40-47. PMID: 24641202
- Gupta AK, Charrette A. Topical minoxidil: systematic review and meta-analysis of its efficacy in androgenetic alopecia. Skinmed. 2016;14(3):189-196. PMID: 27582156
- Bourrat E, Souteyrand P, Cambazard F. Hair care products: what dermatologists should know. Ann Dermatol Venereol. 2012;139(8-9):567-575. PMID: 22882676
- Schmid D, Schürch C, Zgraggen A. Plant stem cells in cosmetic dermatology. J Cosmet Dermatol. 2008;7(4):293-299. PMID: 18492135
- Mibelle Biochemistry. PhytoCellTec Malus Domestica: Plant stem cells for hair care. Mibelle Biochemistry Research Report. 2010.
- Mascot Spincontrol Clinical Research Centre. In-Vitro Evaluation of Hair Care Formulation with Versus Non-Conditioning Shampoo Respect to Volumizing Effect, Tensile Strength, Manual Combing & Sensorial Attributes on Hair Tresses. 2025.